Proteomic identification of novel brain and serum biomarkers linked to the pathophysiology of Duchenne muscular dystrophy


Duchenne muscular dystrophy is the most frequently inherited neuromuscular disease of childhood, and is characterised by primary abnormalities in the Dmd gene encoding the membrane cytoskeletal protein dystrophin. Aside from the well-established skeletal muscle degeneration and cardio-respiratory complications, extra-muscular manifestations are also evident. Comparative label-free liquid chromatography mass spectrometric analyses of brain tissue and serum derived from the mdx-4cv animal model of the disease have identified novel proteomic markers of astrogliosis and inflammation respectively.


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