Tacrolimus treatment in patients with long-standing ocular myasthenia gravis

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Ocular myasthenia gravis (OMG) refers to the disease clinically restricted to extrinsic ocular muscles characterized by impaired neuromuscular transmission. Patients with OMG show long-term disabilities of the ocular symptoms such as ptosis and diplopia which both interfere with daily activities. Although ocular disturbances are the most frequent initial symptoms in myasthenic patients, symptoms usually progress to generalized MG. As corticosteroids reduce the chance of secondary generalization, their use is justified in patients with recent-onset OMG.

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