Urinary titin reveals persistent proteolysis in Duchenne muscular dystrophy

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Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disease caused by lack of dystrophin. The decrease of muscle mass is supposed due to proteolysis of muscle proteins. However, the level of proteolysis is hardy estimated in DMD. Titin, the third most abundant protein in muscle, is reported degraded by calpains. Recently, proteolytic product of titin was shown to be present in the urine of DMD. We have established ELISA system to quantify urinary titin. Here we examined urinary titin level in DMD from children to adults.

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