Random forest approach to assess relationships of subjective muscle fatty infiltration with age at clinical onset and time of disease evolution in LMNA-related muscle disorders


Muscle MRI is a popular approach to orientate genetic studies in clinical practice. Systematic description of muscle infiltration with semiquantitative scores is important to define specific MRI profiles in the different muscle disorders. Recently, two studies have described fatty infiltration patterns in patients with LMNA mutations. One has described whole body MRI in congenital muscular dystrophy (Gómez-Andrés et al. 2016); the other has assessed fatty infiltration of lower limbs by CT or MRI in Emery-Dreifuss and LGMD phenotypes (Díaz-Manera et al.


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