HIV-related cognitive decline despite viral suppression and complex confounds in American women


In this issue of Neurology®, the Women’s Interagency HIV Study (WIHS)1 presents a longitudinal analysis of its American cohort. The cohort is unique because it is large and representative of contemporary women with or at risk of HIV infection the United States. The cohort is ethnically diverse, composed of a substantial number who are economically disadvantaged, and includes participants with mental health issues, including alcohol/drug use (most women report past use of alcohol and recreational drugs, and between 7% and 18% are current users). There were few differences between the women who completed and those who did not complete the study; however, each of the differing characteristics was still well represented for the participants who completed the study (Hispanic ethnicity, smoking, marijuana and efavirenz use, better adherence with combination antiretroviral therapy [cART], shorter duration of ART use, higher CD4+ T cell count).


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