Long-term follow-up of MRI changes in thigh muscles of patients with facioscapulohumeral dystrophy: a quantitative study


Facioscapulohumeral muscular dystrophy (FSHD) has no known effective treatment. Determination of the efficacy of a therapy might be difficult in FSHD given the slow and highly variable disease progression. Our objective was to investigate longitudinally the time-dependent changes occurring in thigh muscles of FSHD patients using quantitative MRI and to assess the potential relationships with the clinical findings. 35 FSHD1 patients were enrolled. Clinical assessment including manual muscle testing (MRC) and motor function measure (MFM) were recorded each year for a period ranging from 1 to 2 years.


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