Muscle alterations in sporadic inclusion body myositis assessed using quantitative nuclear magnetic resonance imaging and spectroscopy, ultrasound shear-wave elastography, and relationships with muscle function


Availability of robust metrics to assess muscle alterations in neuromuscular disorders such as sporadic inclusion body myositis (sIBM) is critical to understand pathophysiology and evaluate therapeutic interventions. Quantitative nuclear magnetic resonance (NMR) imaging (3-point Dixon, multi-TE echo) was performed in thigh and leg muscles of 45 sIBM patients. Water T2 and fat fraction (FF) maps were calculated. Muscle groups were manually segmented and contractile cross-sectional areas (cCSA) were determined.


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