Predominant posterior cerebral cortical atrophy in patients with DMD mutations


Mutations in the DMD gene (Cr Xp21) cause Duchenne (DMD) and Becker (BMD) muscular dystrophies. Both have a progressive course that culminates with inability to walk, respiratory restriction and death. Cognitive and behavioral deficits are also conspicuous in the disease. Despite that, there are few studies looking at the structural basis for such neuropsychiatric manifestations, and none assessing specifically cortical thickness measurements. To determine the structural signature of DMD/BMD at the cerebral cortex level using high-resolution brain MRI.


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