Timing and localization of human dystrophin isoform expression provide insights into the cognitive phenotype of Duchenne muscular dystrophy


Duchenne muscular dystrophy (DMD) has a high incidence of learning and behavioural problems and comorbidity with neurodevelopmental disorders such as autism-spectrum disorders, attention-deficit hyperactivity disorder, obsessive-compulsive disorder, and dyslexia. To gain more insights into the role of dystrophin in this cognitive phenotype, we performed a comprehensive analysis of the expression patterns of dystrophin isoforms across healthy human brain development, using transcriptomic data from Allen Human Brain and BrainSpan atlases.


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