Epileptic seizures heralding a relapse in high grade gliomas


The clinical manifestations of high-grade gliomas (HGG) vary according to the extension of the tumor, its location and its possible clinical complications, which include intracranial hypertension and hemorrhage. Seizures are the first clinical sign in 30–50% of patients, whereas they occur later in the course of the disease in 10–30% of patients [1–3]. Seizures in low-grade, slow-growing tumors, unlike those in HGG which are believed to be caused by neuronal necrosis and hemosiderin deposits, are facilitated by cellular and tissue changes [1].


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