Virus-Mediated Genome Editing via Homology-Directed Repair in Mitotic and Postmitotic Cells in Mammalian Brain

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Nishiyama et al. show that precise genome editing via HDR is possible in mature postmitotic neurons as well as mitotic cells in the mammalian brain by combining CRISPR-Cas9-mediated DNA cleavage and the efficient delivery of donor template with AAV.

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