Endogenous Gαq-Coupled Neuromodulator Receptors Activate Protein Kinase A

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Chen et al. show that hippocampal Gαq-coupled muscarinic receptors activate PKA, an effector classically associated with the Gαs/Gαi pathways. The regulation is mediated by parallel signaling via either Ca2+ or PKC and generalizes to other endogenous and designer Gαq-coupled receptors.

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