Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model

By Stefan A. Berghoff, Tim Düking, Lena Spieth, Jan Winchenbach, Sina K. Stumpf, Nina Gerndt, Kathrin Kusch, Torben Ruhwedel, Wiebke Möbius and Gesine Saher On Dec 2, 2017

In neuroinflammatory disorders such as multiple sclerosis, the physiological function of the blood-brain barrier (BBB) is perturbed, particularly in demyelinating lesions and supposedly secondary to acute demy…