Specific muscle strength is reduced in facioscapulohumeral dystrophy. an MRI based musculoskeletal analysis

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• Specific muscle strength of the quadriceps muscle is reduced in patients with FSHD.• MRI and muscle modeling can be used to evaluate specific muscle strength in FSHD.• FSHD patients have lower contractile muscle volume and PCSA than healthy controls.• Clinical trials for FSHD should aim for restoration of specific muscle strength.

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