α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton

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The synaptic protein α-synuclein has been strongly implicated in neurodegeneration in Parkinson’s disease and related disorders. Using a new Drosophila α-synucleinopathy model, Ordonez et al. show that α-synuclein interacts with spectrin to destabilize the actin cytoskeleton and induce mitochondrial dysfunction.

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