Old Brains Come Uncoupled in Sleep: Slow Wave-Spindle Synchrony, Brain Atrophy, and Forgetting


Helfrich et al. demonstrate that the precise coupling between sleeping brainwaves, called slow waves and spindles, supports memory retention. However, this brainwave coupling during sleep is impaired in older adults due to loss of tissue in the medial frontal lobe, resulting in next-day forgetting.


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