Normal CA1 Place Fields but Discoordinated Network Discharge in a Fmr1-Null Mouse Model of Fragile X Syndrome

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Talbot et al. report normal location-specific hippocampus CA1 place cell responses, but dysregulated synaptic function and discoordinated spike timing in fragile X syndrome (FXS) model mice, pointing to abnormally timed interactions between normally tuned single-neuron responses in FXS-associated intellectual disability and autism.

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