Activity-Dependent Downscaling of Subthreshold Synaptic Inputs during Slow-Wave-Sleep-like Activity In Vivo

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González-Rueda et al. show that presynaptic activation during slow-wave-sleep-like activity in vivo causes synaptic depression, unless it contributes to postsynaptic spiking. This plasticity rule offers an attractive mechanism for circuit refinement that improves signal-to-noise ratio and preserves previously stored information.

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