Association of miR-149 polymorphism with onset age and severity in charcot-marie-tooth disease type 1a


• An association study was conducted between miR-149 SNP and severity of CMT1A.• The rs2292832 SNP was closely associated to the onset age and severity of CMT1A.• The TC and CC genotypes were associated with late onset and mild symptom.• The rs2292832 in miR-149 was suggested as a potential genetic modifier of CMT1A.


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