Association between HLA alleles and lamotrigine-induced cutaneous adverse drug reactions in Asian populations: A meta-analysis

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Aromatic antiepileptic drugs (AEDs), including carbamazepine (CBZ), oxcarbazepine (OXC), lamotrigine (LTG), and phenytoin (PHT), are among the most common causes of cutaneous adverse drug reactions (cADRs) because of their similar structure. The mortality rate of Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) can be as high as 10% and 40%, respectively[1], and aromatic AEDs are among the most common causes of severe cutaneous reactions[2]. cADRs are categorized into bullous and non-bullous skin lesions by pathogenesis [3].

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