The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation

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Nie et al. identify TLR2/4 as crucial mediators of repeated stress-induced microglial activation in the mPFC, which leads to neuronal and behavioral changes through inflammation-related cytokines. These results highlight pivotal roles of innate immunity in the mPFC in repeated stress.

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