Nationwide survey in Japan endorsed diagnostic criteria of benign adult familial myoclonus epilepsy


Benign adult familial myoclonus epilepsy (BAFME) has an autosomal dominant trait, and its primary symptoms are cortical tremor (tremulous myoclonus) mimicking essential tremor and infrequent generalized seizures [1,2]. In Japan, BAFME has been described throughout the late 20th century and has been referred to as cortical tremor [1], BAFME [2], familial cortical myoclonic tremor [3], familial cortical tremor with epilepsy [4], and familial adult myoclonic epilepsy (FAME) [5]. Many similar case reports followed after 2000 in Europe, where different names have been used to refer to the condition, such as, autosomal dominant cortical myoclonus and epilepsy (ADCME) [6], and familial cortical myoclonic tremor with epilepsy (FCMTE) [7].


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