Novel drugs and early polypharmacotherapy in status epilepticus

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Status epilepticus (SE) is a life-threatening medical emergency. Current guidelines recommend rapid stepwise treatment first using benzodiazepines in monotherapy, followed by a sequential addition of second-line drugs if SE continues [1]. Approximately one-third of cases of SE remain refractory (RSE) or super-refractory (SRSE) to treatment with benzodiazepines and second-line drugs [2,3]. RSE refers to an ongoing SE despite two appropriately selected and dosed antiepileptic drugs, including one benzodiazepine [4].

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