Refractory epilepsy in preschool children with tuberous sclerosis complex: Early surgical treatment and outcome


Tuberous sclerosis complex (TSC) is a multisystem disorder with autosomal dominant inheritance and a high rate of de novo pathogenic variants (60%).The incidence of this illness is 1/7000–8000 people. Diagnostic criteria for TSC were first defined by Roach and Gomez [1] and recently reviewed by Northrup [2].


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