Human Autoantibodies against the AMPA Receptor Subunit GluA2 Induce Receptor Reorganization and Memory Dysfunction

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Haselmann et al. explore molecular mechanisms of autoimmune encephalitis with autoantibodies to the AMPA receptor. Human anti-GluA2 autoantibodies induce internalization of AMPA receptors followed by synaptic scaling-like changes leading to defective synaptic transmission and plasticity resulting in memory dysfunction.

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