Human Autoantibodies against the AMPA Receptor Subunit GluA2 Induce Receptor Reorganization and Memory Dysfunction

Haselmann et al. explore molecular mechanisms of autoimmune encephalitis with autoantibodies to the AMPA receptor. Human anti-GluA2 autoantibodies induce internalization of AMPA receptors followed by synaptic scaling-like changes leading to defective synaptic transmission and plasticity resulting in memory dysfunction.