Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression

Heisler et al. demonstrate that prion protein intracellular transport is important for the progression of prion disease. They identify a regulatory mechanism of bidirectional prion protein vesicle trafficking and propose a novel transport pathway that connects intracellular lysosomal degradation with extracellular exosome trafficking under neurodegenerative conditions.