DMD TREATMENT: ANIMAL MODELS

0

Duchenne muscular dystrophy (DMD) occurs due to mutations in dystrophin, a part of the dystrophin-glycoprotein complex (DGC). This complex links the extracellular matrix (ECM) and the myofiber cytoskeleton, protecting the skeletal muscle against contraction-induced damage. Similar to the DGC, the integrin complex functions as a structural link between the ECM and the cytoskeleton, playing an important role in muscle fiber stability. In this complex, Integrin linked kinase (ILK) is responsible for signaling between the ECM and the muscle fiber.

Read More...

Leave A Reply