DMD TREATMENT: ANIMAL MODELS

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Micturition problems are often reported in Duchenne muscular dystrophy with changing symptomatology over time. Here we examined the potential aetiology of this developmental urinary dysfunction by analysing the expression of dystrophin in urinary bladder from 24 h-, two weeks-, four weeks- and six months-old rats. Regional and cellular dystrophin distribution was evaluated by immuhistochemical co-localization studies in adult urinary bladders. This learned that dystrophin was expressed in alpha-smooth muscle actin-positive cells and in some calcitonin gene-related peptide-positive neurons in the lamina propria.

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