NEW INSIGHTS INTO CELLULAR FUNCTIONS

0

Absence of dystrophin protein causes Duchenne muscular dystrophy, which is modeled by the dystrophin deficient mdx mouse. Compared to wildtype muscle, dystrophic mdx muscle is highly susceptible to eccentric contraction induced torque loss. Lack of dystrophin also influences the subsarcolemmal microtubule lattice. Wildtype muscle has a highly organized microtubule lattice of 90° intersections which becomes disorganized in mdx. Three additional mouse lines with disorganized microtubules are also susceptible to eccentric contraction induced torque loss, insinuating that microtubule lattice aberrations may contribute to the susceptibility of dystrophic muscle to eccentric contraction.

Read More...

Leave A Reply