REGISTRIES AND CARE OF NEUROMUSCULAR DISORDERS

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Our objective is to develop a multi-pathway therapeutic approach to the treatment of neurodegenerative diseases like ALS and spinal cord injury (SCI). A major contributor to the pathology of neurogenerative conditions is the excessive inflammation in the CNS, mediated by T lymphocytes, M1-type macrophages and microglia. This has been associated with tissue destruction, neuroaxonal injury and inhibition of axon regeneration. miR-155 is a pro-inflammatory microRNA highly upregulated in activated immune cells, where it mediates cell proliferation and survival, and drives the inflammatory response.

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