Review on the Relevance of Therapeutic Drug Monitoring of Levetiracetam

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In clinical practice, most dosing schemes for pharmacological treatment of epilepsy are based on efficacy (i.e. seizure reduction) and tolerability (i.e. side-effects). However, one can anticipate clinical effects (efficacy and tolerability) by measuring anti-epileptic drug (AED) serum drug concentrations (SDCs). This constellation is true for some older AEDs, such as phenytoin, since they imply regular monitoring of SDCs due to their non-linear pharmacokinetics and/or small therapeutic range [1].

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