Alcohol Activates Scabrous-Notch to Influence Associated Memories

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One of the many challenges with battling alcohol and substance use disorders is the risk of relapse. This study aims to understand the molecular basis of cravings associated with relapse by demonstrating how alcohol hijacks the Notch signaling pathway. The authors found that alcohol activates Notch in a memory circuit in the fruit fly, Drosophila melanogaster, and that this is associated with misregulation of gene isoforms associated with memory formation. These findings provide insight into how alcohol induces such long-lasting cravings.

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