Engram Cell Excitability State Determines the Efficacy of Memory Retrieval


Memory exists across different time scales. Long-term memories can last a lifetime, while working memory persists for mere seconds. In between, memories that are newly formed—or recently recalled—are more vivid than latent ones. How does this happen? The act of memory recall increases the excitability of whole engram cells for about one hour. This short-term increase of engram cell excitability facilitates synaptic access to memory content in response to relevant environmental cues.


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