Association between HLA-A*3201 allele and oxcarbazepine-induced cutaneous adverse reactions in Eastern Han Chinese population


Epilepsy is one of the most common neurological conditions, with more than 2% of the population worldwide affected according to the latest study [1]. As a chronic disease, epilepsy requires long-term treatment with anti-epileptic drugs (AEDs) [2]. Moreover, up to 30% of patients with epilepsy remain resistant to the standard therapy despite the multitude of available AEDs such as carbamazepine (CBZ), sodium valproate, and phenytoin (PHT) [3,4]. Oxcarbazepine (OXC), a 10-keto derivative of CBZ, has emerged as a relatively new AED.


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