A Selectivity Filter Gate Controls Voltage-Gated Calcium Channel Calcium-Dependent Inactivation

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Calcium-dependent inactivation (CDI) is essential for voltage-gated calcium channel (CaV) autoregulation. Abderemane-Ali et al. demonstrate that the CaV selectivity filter (SF) forms the CDI gate, suggesting an SF-based inactivation paradigm shared with other voltage-gated ion channel (VGIC) superfamily members.

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