Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instructs Neuronal Polarity

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Farías et al. report that the localization of the endoplasmic reticulum (ER) in the axon is controlled by the interaction between ER-shaping proteins and the microtubule cytoskeleton. Local ER and microtubule crosstalk promotes ER tubule-microtubule stabilization and drives neuronal polarity.

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