Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats

By Susanne Bäck, Julie Necarsulmer, Leslie R. Whitaker, Lamarque M. Coke, Pyry Koivula, Emily J. Heathward, Lowella V. Fortuno, Yajun Zhang, C. Grace Yeh, Heather A. Baldwin, Morgan D. Spencer, Carlos A. Mejias-Aponte, James Pickel, Alexander F. Hoffman, Charles E. Spivak, Carl R. Lupica, Suzanne M. Underhill, Susan G. Amara, Andrii Domanskyi, Jenni E. Anttila, Mikko Airavaara, Bruce T. Hope, F. Kent Hamra, Christopher T. Richie, Brandon K. Harvey On Feb 18, 2019

Limited availability of transgenic rats has hindered their utility in modeling human behavior and cognition. Bäck, Necarsulmer, et al. describe new transgenic rats and viral vectors that enable neuron- and region-specific gene modifications within the adult rat brain.