Association of cutaneous adverse drug reactions due to antiepileptic drugs with HLA alleles in a North Indian Population


Antiepileptic drugs (AEDs), particularly aromatic ones like Carbamazepine (CBZ), Phenytoin (PHT), Phenobarbitone (PB), and Lamotrigine (LTG), are responsible for various cutaneous adverse drug reactions (cADRs). These vary from minor Maculopapular exanthema (MPE) to severe life-threatening reactions like Drug reaction eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN), which may develop within few hours to even several weeks after AED initiation.


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