Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer’s disease

By Sarmi Sri, Chrysia-Maria Pegasiou, Chantal Abbigail Cave, Katie Hough, Natalie Wood, Diego Gomez-Nicola, Katrin Deinhardt, David Bannerman, V. Hugh Perry and Mariana Vargas-Caballero On Feb 23, 2019

The synaptic changes underlying the onset of cognitive impairment in Alzheimer’s disease (AD) are poorly understood. In contrast to the well documented inhibition of long-term potentiation (LTP) in CA3-CA1 syn…

neuropathology

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α-Synuclein and astrocytes: tracing the pathways from homeostasis to neurodegeneration in Lewy body disease

Accumulation of prion protein in the vagus nerve in Creutzfeldt‐Jakob disease