Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways

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At excitatory synapses on CA1 pyramidal neurons lacking neuroligins, Nlgn1 rescues impairments in functional and structural LTP and in NMDA receptor-mediated synaptic transmission. Structure-function rescue experiments reveal that Nlgn1 plays mechanistically distinct roles in LTP and basal NMDA receptor-mediated transmission.

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