Transient Confinement of CaV2.1 Ca2+-Channel Splice Variants Shapes Synaptic Short-Term Plasticity

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Presynaptic CaV2.1 channels are confined in nanodomains, for which size and dwell time are modulated by network activity. Heck et al. show that changing the affinity to scaffold proteins by alternative splicing of CaV2.1 directly affects short-term plasticity.

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