Valproate Decreases Vitamin D Levels in Pediatric Patients with Epilepsy

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Individuals with epilepsy being treated with chronic antiepileptic drug (AED) therapy represent approximately 1% of the general population [1,2]. Vitamin D (Vit D) deficiency is commonly reported in adult patients with epilepsy on AED therapy [3], particularly in patients on older AEDs that induce hepatic metabolism such as carbamazepine and phenobarbital [4]. Valproate and other newer AEDs (e.g. lamotrigine, oxcarbazepine) are generally considered to have minimal effects on hepatic metabolic enzymes, and thus, considered to have a lower potential to affect Vit D levels [5–7].

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