An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity

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AMPA-receptors are key players of excitatory neurotransmission and learning. Schwenk et al. show that assembly of native AMPARs in the ER occurs in discrete steps determined by ER-resident interactors; disturbance of this assembly phenocopies the severe intellectual disability in patients.

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