Heterosynaptic Plasticity Determines the Set Point for Cortical Excitatory-Inhibitory Balance

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After induction of synaptic plasticity at specific inputs, Field et al. found that coordinated changes occur across multiple inhibitory and excitatory inputs onto cortical pyramidal neurons. The relative timing and degree of heterosynaptic plasticity determines the overall excitatory-inhibitory correlation, i.e., the set point for excitatory-inhibitory balance.

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