Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis

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Neurons display different levels of vulnerability to Alzheimer’s pathology. Roussarie et al. experimentally profile and computationally model several relevant neuron types. Using a mouse-human framework, they identify genes linking Aß, aging, and tau in vulnerable neurons. Finally, they show experimentally that PTB, a regulator of tau splicing, contributes to vulnerability.

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