Expiratory Muscle Strength Training improves measures of pressure generation and cough strength in a patient with Myotonic Dystrophy Type 1


Myotonic dystrophy type 1 (DM1) is the most prevalent neuromuscular disease in adults and affects 1 in 8000 people worldwide [1]. It is a progressive multisystem genetic disorder caused by an unstable trinucleotide CTG repeat expansion in untranslated DNA of the DMPK gene. There is a modest positive correlation between the CTG repeat expansion, an earlier age of symptom onset, and disease severity [2]. People can be divided into four main subtypes of DM1: congenital, childhood-onset, adult-onset and late onset based on the age of onset of their symptoms with younger onset patients having increased CTG repeats and more severe disease severity.


Leave A Reply