Insulin-like Growth Factor-1 Status Is Associated with Insulin Resistance in Young Patients with Spinal Muscular Atrophy

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Growth hormone (GH) is a key player in linear growth during childhood and adolescence and a major determinant of insulin-like growth factor-1 (IGF-1). Circulating IGF-1 is synthesized predominantly in the liver upon GH stimulation. IGF-1 is crucial in the development of muscle and bone in children and their maintenance in adulthood. It has a myotrophic effect, exerting a significant anabolic effect on muscle tissue with impact on both muscle mass and performance (1-4). Importantly, IGF-1 deficiency or resistance can exacerbate the process of muscle tissue loss (5).

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