Epilepsy surgery for pediatric patients with mild malformation of cortical development


According to Palmini’s classification, the presence of “excess” heterotopic neurons in the molecular layer or white matter is classified as mild malformation of cortical development (mMCD). [1,2] Excess heterotopic neurons in white matter are a frequent pathological finding in many epilepsy surgery specimens, either in isolation or near the epileptogenic lesion [3–5].However, no exact pathomechanistic hypotheses have arisen from this observation, and its role in the causation of epilepsy is debatable [6,7].A few studies correlating mMCD findings with clinical parameters have had small sample sizes and report inconsistent results [8–11].


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