Recent antiepileptic and neuroprotective applications of brain cooling

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Epilepsy is a heterogeneous group of chronic neurological disorders that are characterized by recurrent unprovoked seizures. Epileptic seizures occur when neurons are intermittently activated in an abnormally excessive and highly synchronous manner. Focal and generalized seizures are distinguished according to the localization of activated neurons. The onset of a focal seizure is limited to a part of one hemisphere, during generalized seizures, the initial activation of neurons happen throughout both hemispheres [1].

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