Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia

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While investigating why regenerated axons fail to be myelinated in injured optic nerves, Wang et al. find that injury-induced GPR17 expression in OPCs and chronically activated microglia suppress different steps of OPC differentiation. Co-manipulation of intrinsic (GPR17) and extrinsic (microglia) factors promotes extensive myelination of regenerated axons in an inflammatory environment.

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