Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia


While investigating why regenerated axons fail to be myelinated in injured optic nerves, Wang et al. find that injury-induced GPR17 expression in OPCs and chronically activated microglia suppress different steps of OPC differentiation. Co-manipulation of intrinsic (GPR17) and extrinsic (microglia) factors promotes extensive myelination of regenerated axons in an inflammatory environment.


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